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NERVOUS SYSTEM › ANESTHETICS › ANESTHETICS, LOCAL › Esters of aminobenzoic acid
benzocaine
N01BA05
Forms & Strengths
- Topical spray 20%
- Lozenges 5mg, 10mg, 15mg, 20mg
- Gel 10%, 20%
- Liquid 10%, 20%
- Aerosol spray 20%
Adult Dosing
- Apply 0.5-2 mL of 20% topical solution to affected area
- One to two lozenges (5-20mg) every 2 hours as needed
- Do not exceed 8 lozenges (40-160mg) in 24 hours
Pediatric Dosing
- For children over 3 years, apply 0.5 mL of 20% topical solution to affected area
- For children over 3 years, one lozenge (5mg) every 2 hours as needed
- Do not exceed 4 lozenges (20mg) in 24 hours for children 3-12 years
Indications
- Temporary relief of pain and discomfort due to toothaches
- Sore throats
- Minor cuts and burns
- Minor skin irritations
- Hemorrhoid relief
Mechanism of Action
- Local anesthetic by blocking sodium ion entry
- Stabilizes neuronal membrane
- Prevents initiation and transmission of nerve impulses
Contraindications
- Hypersensitivity to benzocaine or other ester-type local anesthetics
- Infants under 3 months due to risk of methemoglobinemia
Adverse Reactions
- Methemoglobinemia
- Allergic reactions
- Contact dermatitis
- Burning sensation
- Numbness
Drug Interactions
- Sulfonamides may increase risk of methemoglobinemia
- Nitric oxide donors may increase risk of methemoglobinemia
- Other local anesthetics may increase risk of systemic toxicity
Curated Content: Needs Vetting Before Put to Clinical Use