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cinchocaine

N01BB06

Forms & Strengths

Ointment: 0.5%
Cream: 0.5%
Suppositories: 1 mg, 2 mg
Solution for spinal anesthesia: 0.5% (Heavy)

Adult Dosing

Anorectal conditions (ointment/cream/suppositories): Apply to affected area 2-3 times daily.
Spinal anesthesia (heavy solution): 5-10 mg intrathecally, adjusted based on patient factors and desired level of anesthesia.

Pediatric Dosing

Safety and efficacy in pediatric patients are not well established; use generally avoided or restricted to specialized clinical settings.

Indications

Symptomatic relief of pain, itching, and inflammation associated with hemorrhoids and other anorectal disorders.
Spinal anesthesia for surgical procedures.

Mechanism of Action

Amide-type local anesthetic that stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local local anesthesia.

Contraindications

Hypersensitivity to cinchocaine (dibucaine), other amide-type local anesthetics, or any component of the formulation.
Presence of local infection at the site of application/injection.
Severe shock or heart block (for spinal administration).

Adverse Reactions

Local irritation, burning, or stinging at the application site
Allergic contact dermatitis
Hypotension and bradycardia (with spinal administration)
Central nervous system toxicity (tinnitus, dizziness, seizures) in systemic overload
Methemoglobinemia (rare)

Drug Interactions

Other local anesthetics (additive systemic toxicity)
Antiarrhythmic agents (e.g., amiodarone, mexiletine) due to additive cardiac depression
Monoamine oxidase inhibitors or tricyclic antidepressants (increased risk of severe blood pressure fluctuations when used with spinal anesthesia)

Curated Content: Needs Vetting Before Put to Clinical Use