← Search & browse all drugs

etidocaine, combinations

N01BB57

Forms & Strengths

Injectable solution: etidocaine hydrochloride 1% to 1.5% with epinephrine 1:200,000

Adult Dosing

Infiltration/nerve block: 50 mg to 300 mg (5 to 30 mL of 1% solution) depending on procedure
Max recommended dose without epinephrine: 4 mg/kg (not to exceed 300 mg)
Max recommended dose with epinephrine: 5 mg/kg (not to exceed 400 mg)

Pediatric Dosing

Safety and efficacy in pediatric patients under 12 years of age have not been established

Indications

Production of local or regional anesthesia by infiltration, peripheral nerve block, and epidural block

Mechanism of Action

Amide-type local anesthetic that stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action

Contraindications

Known hypersensitivity to local anesthetics of the amide type
Concomitant use with obstetrical paracervical block (associated with high fetal bradycardia and mortality)
Severe degrees of atrioventricular block when used for epidural anesthesia

Adverse Reactions

Central nervous system: CNS excitation and/or depression, dizziness, nervousness, apprehension, euphoria, confusion, drowsiness, convulsions, unconsciousness
Cardiovascular system: Myocardial depression, hypotension, bradycardia, ventricular arrhythmias, cardiac arrest
Allergic: Urticaria, edema, anaphylactoid reactions
Neurologic: Persistent anesthesia, paresthesia, weakness of lower extremities

Drug Interactions

Class III antiarrhythmic drugs (e.g., amiodarone): additive cardiac effects
Other local anesthetics or agents structurally related to amide-type local anesthetics: additive systemic toxicity
Monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants: severe or prolonged hypertension when combined with epinephrine-containing solutions

Curated Content: Needs Vetting Before Put to Clinical Use