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oxycodone and naltrexone

N02AA56

Forms & Strengths

controlled-release tablets: 10mg/4mg, 20mg/8mg, 40mg/16mg, 80mg/32mg oxycodone/naltrexone
oral tablets

Adult Dosing

10-40mg oxycodone every 12 hours for opioid-naive patients
20-80mg oxycodone every 12 hours for opioid-experienced patients
do not exceed maximum daily dose

Pediatric Dosing

safety and efficacy not established in pediatric patients
use with caution in patients 11-16 years old
consult pediatric specialist before use

Indications

management of moderate to severe pain
treatment of chronic pain requiring around-the-clock opioid analgesia
not for acute pain or on an as-needed basis

Mechanism of Action

oxycodone: mu-opioid receptor agonist
naltrexone: mu-opioid receptor antagonist
naltrexone sequestered within tablet to prevent euphoria

Contraindications

hypersensitivity to oxycodone, naltrexone, or other opioids
acute or severe bronchial asthma
known or suspected paralytic ileus

Adverse Reactions

nausea and vomiting
constipation
dizziness and somnolence
respiratory depression
anaphylaxis and angioedema

Drug Interactions

CYP3A4 inhibitors: contraindicated, may cause increased oxycodone concentrations
CYP3A4 inducers: monitor for decreased oxycodone efficacy
other CNS depressants: use with caution, may increase sedative effects

Curated Content: Needs Vetting Before Put to Clinical Use