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piritramide

N02AC03

Forms & Strengths

Solution for injection: 10 mg/mL

Adult Dosing

Subcutaneous or intramuscular injection: 15 mg (range 7.5-30 mg) as needed
Slow intravenous injection: 7.5-15 mg titrated to pain relief
Maximum daily dose and dosing interval must be individualized based on clinical response and tolerance

Pediatric Dosing

Safety and efficacy in pediatric patients are not well established; use generally not recommended or restricted to specialized pediatric anesthesia settings

Indications

Management of severe acute and chronic pain
Premedication and postoperative pain management

Mechanism of Action

Potent full mu-opioid receptor agonist in the central nervous system
Inhibits ascending pain pathways, alters perception of and response to pain, and produces CNS depression

Contraindications

Hypersensitivity to piritramide
Severe respiratory depression or acute respiratory insufficiency
Acute bronchial asthma
Paralytic ileus
Coma

Adverse Reactions

Respiratory depression
Sedation, somnolence, dizziness
Nausea and vomiting
Constipation
Urinary retention
Hypotension, bradycardia
Pruritus, sweating

Drug Interactions

CNS depressants (alcohol, benzodiazepines, barbiturates, general anesthetics): profound sedation, respiratory depression, coma, and death
MAO inhibitors: potential for severe potentiation leading to CNS excitation or depression
Mixed agonist-antagonist opioids (e.g., buprenorphine, pentazocine): may precipitate withdrawal symptoms or reduce analgesic efficacy

Curated Content: Needs Vetting Before Put to Clinical Use