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NERVOUS SYSTEM › ANALGESICS › OPIOIDS › Benzomorphan derivatives
phenazocine
N02AD02
Adult Dosing
- Moderate to severe pain: 5 mg orally up to TID as needed
Pediatric Dosing
- Safety and efficacy in pediatric patients not established
Indications
- Management of moderate to severe pain
Mechanism of Action
- Synthetic benzomorphan derivative acting primarily as an agonist at mu- and kappa-opioid receptors in the central nervous system, altering perception of and response to pain
Contraindications
- Hypersensitivity to phenazocine
- Significant respiratory depression
- Acute or severe bronchial asthma in an unmonitored setting
- Known or suspected gastrointestinal obstruction, including paralytic ileus
Adverse Reactions
- Respiratory depression
- Sedation and drowsiness
- Dizziness and lightheadedness
- Nausea and vomiting
- Constipation
- Pruritus and sweating
Drug Interactions
- Central nervous system depressants (alcohol, benzodiazepines, sedatives) increase risk of profound sedation, respiratory depression, coma, and death
- Monoamine oxidase inhibitors (MAOIs) may precipitate severe unpredictable hyperactive or hypotensive reactions
- Mixed agonist/antagonist opioid analgesics may reduce analgesic effect or precipitate withdrawal symptoms
Curated Content: Needs Vetting Before Put to Clinical Use