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NERVOUS SYSTEM › ANALGESICS › OPIOIDS › Opioids in combination with non-opioid analgesics
oxycodone and acetylsalicylic acid
N02AJ18
Forms & Strengths
- Tablet: Oxycodone hydrochloride 4.5 mg / Aspirin 325 mg
- Tablet: Oxycodone hydrochloride 4.8355 mg / Aspirin 325 mg
- Tablet: Oxycodone terephthalate 2.24 mg / Aspirin 325 mg
Adult Dosing
- Moderate to moderately severe pain: 1 tablet orally every 6 hours as needed
- Dosing must be titrated based on pain severity, response, and patient age
- Maximum daily dose limited by the aspirin (salicylate) component to avoid toxicity
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
- Not recommended for use in children and adolescents due to the aspirin component (Reye's syndrome risk)
Indications
- Management of moderate to moderately severe pain where combination opioid and NSAID therapy is appropriate
Mechanism of Action
- Oxycodone: Mu-opioid receptor agonist providing central analgesia
- Acetylsalicylic acid (Aspirin): Inhibits cyclooxygenase (COX-1 and COX-2), reducing prostaglandin synthesis for peripheral anti-inflammatory, analgesic, and antipyretic effects
Contraindications
- Known hypersensitivity to oxycodone, aspirin, or other salicylates
- Significant respiratory depression
- Acute or severe bronchial asthma or hypercarbia
- Known or suspected gastrointestinal obstruction, including paralytic ileus
- Children and teenagers with viral infections (flu- or chickenpox-related) due to Reye's syndrome risk
- Active peptic ulcer disease or bleeding disorders
Adverse Reactions
- Central nervous system depression, dizziness, drowsiness, sedation
- Respiratory depression
- Gastrointestinal: nausea, vomiting, constipation, dyspepsia, GI bleeding
- Hypersensitivity reactions, rash, bronchospasm
- Increased bleeding time due to antiplatelet effects of aspirin
Drug Interactions
- Central nervous system depressants (alcohol, sedatives, hypnotics, tranquilizers): profound sedation, respiratory depression, coma
- Anticoagulants and antiplatelet agents: increased risk of bleeding
- NSAIDs and corticosteroids: increased risk of gastrointestinal ulceration and bleeding
- CYP3A4 and CYP2D6 inhibitors/inducers: alter oxycodone metabolism and plasma levels
- ACE inhibitors, ARBs, and diuretics: decreased antihypertensive effect and increased risk of renal impairment
Curated Content: Needs Vetting Before Put to Clinical Use