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NERVOUS SYSTEM › ANALGESICS › OPIOIDS › Other opioids
meptazinol
N02AX05
Forms & Strengths
- Tablet 200 mg
- Solution for injection 100 mg/mL
Adult Dosing
- Acute moderate to severe pain: 200 mg orally every 3 to 6 hours as needed
- Intramuscular/Intravenous: 50 mg to 100 mg every 2 to 4 hours as needed
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Management of moderate to severe acute pain
- Obstetric analgesia during labor
Mechanism of Action
- Partial agonist at mu-opioid receptors
- Acts primarily on the mu-1 receptor subtype
- Produces analgesia with a lower incidence of respiratory depression compared to full mu agonists
Contraindications
- Hypersensitivity to meptazinol
- Severe respiratory depression
- Acute or severe bronchial asthma in an unmonitored setting
- Known or suspected gastrointestinal obstruction, including paralytic ileus
Adverse Reactions
- Dizziness
- Nausea and vomiting
- Somnolence
- Sweating
- Epigastric pain
- Mild respiratory depression
Drug Interactions
- Central nervous system depressants (alcohol, barbiturates, benzodiazepines) increase risk of sedation and respiratory depression
- Mixed agonist-antagonist opioids may precipitate withdrawal symptoms in opioid-dependent patients
Curated Content: Needs Vetting Before Put to Clinical Use