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NERVOUS SYSTEM › ANALGESICS › OTHER ANALGESICS AND ANTIPYRETICS › Salicylic acid and derivatives
potassium salicylate
N02BA12
Forms & Strengths
- tablets: 325mg
- solution: 500mg/5mL
Adult Dosing
- Anti-inflammatory: 325-650mg q4-6h
- Analgesic: 325-1000mg q4-6h
- Antipyretic: 325-650mg q4-6h
Pediatric Dosing
- Infants >3 months and children: 8-14mg/kg/dose q4-6h, max: 4 doses/24h
- Children >12 years: same as adult
Indications
- Mild to moderate pain
- Fever reduction
- Rheumatoid arthritis
- Osteoarthritis
Mechanism of Action
- Inhibits COX-1 and COX-2 enzymes
- Blocks prostaglandin synthesis
- Interferes with pain pathways in CNS
Contraindications
- Hypersensitivity to salicylates
- Bleeding disorders
- Liver or kidney impairment
- Asthma with nasal polyps and rhinitis
Adverse Reactions
- Gastrointestinal upset
- Bleeding
- Ringing in the ears
- Hearing loss
- Nausea and vomiting
Drug Interactions
- Warfarin: increased anticoagulation
- Methotrexate: increased toxicity
- Diuretics: increased salicylate toxicity
- Aspirin: avoid concomitant use
Curated Content: Needs Vetting Before Put to Clinical Use