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NERVOUS SYSTEM › ANALGESICS › OTHER ANALGESICS AND ANTIPYRETICS › Salicylic acid and derivatives
guacetisal
N02BA14
Adult Dosing
- Analgesic/Antipyretic: 500 mg to 1 g orally every 4 to 6 hours as needed
- Maximum daily dose: 3 g per day
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established; use is generally avoided in children and adolescents due to Reye's syndrome risk associated with salicylates
Indications
- Management of mild to moderate pain
- Treatment of fever and inflammatory conditions
Mechanism of Action
- Acts as a salicylate derivative and non-steroidal anti-inflammatory drug (NSAID)
- Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, decreasing the synthesis of prostaglandins involved in pain, fever, and inflammation
Contraindications
- Hypersensitivity to guacetisal, acetylsalicylic acid, or other salicylates/NSAIDs
- Active peptic ulcer disease or gastrointestinal bleeding
- Bleeding disorders (e.g., hemophilia, thrombocytopenia)
- Severe hepatic or renal impairment
- Children and adolescents with viral infections due to risk of Reye's syndrome
Adverse Reactions
- Dyspepsia, nausea, and epigastric discomfort
- Increased risk of gastrointestinal ulceration and hemorrhage
- Increased bleeding time due to antiplatelet effects
- Hypersensitivity reactions including rash, bronchospasm, and angioedema
- Tinnitus with high doses
Drug Interactions
- Anticoagulants and antiplatelet agents: Increased risk of severe bleeding
- Other NSAIDs and corticosteroids: Increased risk of gastrointestinal adverse effects and ulceration
- Methotrexate: Decreased renal clearance, leading to increased toxicity
- Antihypertensives and diuretics: Reduced efficacy due to inhibition of renal prostaglandins
Curated Content: Needs Vetting Before Put to Clinical Use