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NERVOUS SYSTEM › ANALGESICS › OTHER ANALGESICS AND ANTIPYRETICS › Salicylic acid and derivatives
acetylsalicylic acid, combinations excl. psycholeptics
N02BA51
Forms & Strengths
- Tablets: 81mg, 325mg, 500mg
- Capsules: 325mg, 500mg
- Suppositories: 60mg, 120mg, 200mg, 300mg, 400mg, 600mg
- Extended-release tablets: 325mg, 650mg, 800mg, 1000mg
Adult Dosing
- Pain relief: 325-1000mg every 4-6 hours as needed
- Anti-inflammatory: 1000-2000mg every 4-6 hours as needed
- Cardiovascular protection: 75-100mg daily
Pediatric Dosing
- Pain relief (6-12 years): 10-15mg/kg/dose every 4-6 hours, maximum 4g/day
- Pain relief (1-3 years): 10mg/kg/dose every 4-6 hours, maximum 2g/day
- Kawasaki disease: 100mg/kg/day divided every 6 hours during acute phase
Indications
- Pain relief
- Fever reduction
- Inflammatory disorders (e.g. rheumatoid arthritis, osteoarthritis)
- Cardiovascular protection (e.g. myocardial infarction, ischemic stroke)
Mechanism of Action
- Cyclooxygenase (COX-1 and COX-2) inhibition
- Prostaglandin synthesis inhibition
- Platelet aggregation inhibition
Contraindications
- Active peptic ulcer disease
- Bleeding disorders (e.g. hemophilia, thrombocytopenia)
- Aspirin allergy
- Asthma with nasal polyps and/or angioedema
Adverse Reactions
- Gastrointestinal upset
- Nausea and vomiting
- Abdominal pain
- Bleeding and bruising
- Tinnitus and hearing loss
- Reye's syndrome (rare, in children)
Drug Interactions
- Anticoagulants (e.g. warfarin, heparin): increased bleeding risk
- Corticosteroids: increased risk of gastrointestinal bleeding
- Methotrexate: increased toxicity
- ACE inhibitors: decreased antihypertensive effect
Curated Content: Needs Vetting Before Put to Clinical Use