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NERVOUS SYSTEM › ANALGESICS › OTHER ANALGESICS AND ANTIPYRETICS › Salicylic acid and derivatives
salicylamide, combinations with psycholeptics
N02BA75
Forms & Strengths
- Tablets: 100mg + 5mg butalbital + 30mg caffeine
- Capsules: 150mg + 15mg butalbital + 30mg caffeine
- Solution: variable combinations with psycholeptics
Adult Dosing
- 1-2 tablets or capsules every 4 hours as needed
- Do not exceed 6 tablets or capsules in 24 hours
- Use lowest effective dose for shortest duration
Pediatric Dosing
- Not recommended under 12 years of age
- 12-16 years, use with caution and under medical supervision
Indications
- Relief of mild to moderate pain
- Treatment of tension headaches
- Temporary relief of headache, fever, and other symptoms
Mechanism of Action
- Salicylamide inhibits prostaglandin synthesis
- Butalbital acts as a central nervous system depressant
- Caffeine has analgesic and CNS stimulant effects
Contraindications
- Hypersensitivity to salicylamide or barbiturates
- Porphyria
- Severe respiratory disease
- Chronic use in patients with hepatic or renal impairment
Adverse Reactions
- Drowsiness
- Dizziness
- Nausea
- Vomiting
- Allergic reactions
Drug Interactions
- Enhanced CNS depression with other sedatives
- Increased risk of bleeding with anticoagulants
- Reduced efficacy of salicylamide with activated charcoal
Curated Content: Needs Vetting Before Put to Clinical Use