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NERVOUS SYSTEM › ANALGESICS › OTHER ANALGESICS AND ANTIPYRETICS › Pyrazolones
phenazone, combinations excl. psycholeptics
N02BB51
Forms & Strengths
- Otic solution: Phenazone 4% + Benzocaine 5%
Adult Dosing
- Instill 3 to 4 drops into the external auditory canal 2 to 3 times daily as needed for pain.
Pediatric Dosing
- Infants and children: Instill 2 to 3 drops into the external auditory canal 2 to 3 times daily as needed for pain.
Indications
- Temporary relief of acute otitis media pain (analgesic and decongestant)
- Removal of cerumen
Mechanism of Action
- Phenazone provides local analgesic and anti-inflammatory effects via prostaglandin synthesis inhibition.
- Benzocaine acts as a local anesthetic by blocking nerve conduction through sodium channel inhibition.
Contraindications
- Hypersensitivity to phenazone, pyrazolone derivatives, or local anesthetics (e.g., benzocaine, procaine)
- Perforated tympanic membrane or suspected perforation
Adverse Reactions
- Local hypersensitivity reactions
- Contact dermatitis
- Pruritus and irritation at the application site
Drug Interactions
- Potential additive local irritation with other topical otic preparations
- Systemic interactions are minimal due to low systemic absorption from topical otic administration
Curated Content: Needs Vetting Before Put to Clinical Use