← Search & browse all drugs
NERVOUS SYSTEM › ANALGESICS › OTHER ANALGESICS AND ANTIPYRETICS › Pyrazolones
propyphenazone, combinations excl. psycholeptics
N02BB54
Forms & Strengths
- Capsules: 50mg, 100mg
- Tablets: 50mg, 100mg, 200mg
- Injectable: 50mg/mL, 100mg/mL
Adult Dosing
- Oral: 50-100mg every 4-6 hours as needed
- IM/IV: 50-100mg every 4-6 hours as needed
- Max daily dose: 400mg
Pediatric Dosing
- Oral: 1-2mg/kg every 4-6 hours as needed
- Max daily dose: 6mg/kg or 200mg
Indications
- Treatment of mild to moderate pain
- Relief of headaches, including tension headaches
- Treatment of muscle and joint pain
- Reduction of fever
Mechanism of Action
- Inhibits prostaglandin synthesis
- Blocks pain impulse transmission
- Exerts anti-inflammatory and antipyretic effects
Contraindications
- Hypersensitivity to propyphenazone
- Active peptic ulcer disease
- Severe renal or hepatic impairment
- Third trimester of pregnancy
Adverse Reactions
- Gastrointestinal disturbances
- Headache, dizziness
- Drowsiness, fatigue
- Skin rash, pruritus
Drug Interactions
- Increased risk of bleeding with anticoagulants
- Reduced efficacy with barbiturates, carbamazepine
- Increased toxicity with lithium, methotrexate
Curated Content: Needs Vetting Before Put to Clinical Use