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NERVOUS SYSTEM › ANALGESICS › OTHER ANALGESICS AND ANTIPYRETICS › Pyrazolones
propyphenazone, combinations with psycholeptics
N02BB74
Forms & Strengths
- Tablets: 150mg, 200mg, 250mg
- Capsules: 100mg, 150mg
- Injectable solution: 50mg/mL
Adult Dosing
- 50-100mg IM/IV as a single dose
- 100-200mg orally every 4-6 hours
- Maximum daily dose: 600mg
Pediatric Dosing
- Not recommended for children under 12 years
- 12-15 years: 50mg orally every 4-6 hours
- Maximum daily dose: 200mg
Indications
- Mild to moderate pain relief
- Fever reduction
- Headache
- Toothache
- Muscle ache
Mechanism of Action
- Inhibition of prostaglandin synthesis
- Blockade of pain impulse transmission
- Anti-inflammatory effects
Contraindications
- Hypersensitivity to propyphenazone
- Severe liver or kidney disease
- Active peptic ulcer
- Bronchial asthma
Adverse Reactions
- Gastrointestinal upset
- Nausea
- Vomiting
- Dizziness
- Headache
- Allergic reactions
Drug Interactions
- Increased risk of bleeding with anticoagulants
- Enhanced sedation with CNS depressants
- Reduced efficacy of diuretics
- Interference with blood glucose control
Curated Content: Needs Vetting Before Put to Clinical Use