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NERVOUS SYSTEM › ANALGESICS › OTHER ANALGESICS AND ANTIPYRETICS › Anilides
propacetamol
N02BE05
Forms & Strengths
- Tablet: 500mg
- Injection: 1g/2mL, 2g/4mL, 5g/10mL
- Suppository: 500mg, 1000mg
Adult Dosing
- 500-1000mg every 4-6 hours as needed
- Maximum daily dose: 4g
- Do not exceed recommended dose
Pediatric Dosing
- 20-40mg/kg every 4-6 hours as needed
- Age 3 months to 1 year: 60-120mg every 4-6 hours
- Age 1-12 years: 250-500mg every 4-6 hours
Indications
- Relief of mild to moderate pain
- Treatment of fever
- Short-term management of pain and discomfort
Mechanism of Action
- Rapidly hydrolyzed to paracetamol
- Inhibits prostaglandin synthesis in the CNS
- Has analgesic and antipyretic effects
Contraindications
- Hypersensitivity to propacetamol or paracetamol
- Severe hepatic impairment
- Chronic alcohol abuse
Adverse Reactions
- Nausea and vomiting
- Abdominal pain
- Hepatotoxicity (rare)
- Allergic reactions (rare)
Drug Interactions
- Increased risk of hepatotoxicity with concurrent use of warfarin
- Concomitant use with barbiturates, carbamazepine, or phenytoin may increase risk of liver damage
- Enhanced analgesic effect with concurrent use of opioids
Curated Content: Needs Vetting Before Put to Clinical Use