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NERVOUS SYSTEM › ANALGESICS › OTHER ANALGESICS AND ANTIPYRETICS › Gabapentinoids
mirogabalin
N02BF03
Forms & Strengths
- Oral tablets: 2.5 mg, 5 mg, 10 mg, 15 mg
Adult Dosing
- Initial dose: 5 mg orally twice daily
- Titration: Increase by 5 mg increments at intervals of at least 1 week
- Maximum dose: 15 mg orally twice daily
- Renal impairment adjustment: Reduce dose for CrCl < 60 mL/min
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Diabetic peripheral neuropathic pain
- Post-herpetic neuralgia
Mechanism of Action
- Binds selectively to the alpha-2-delta (alpha2delta) subunit of voltage-gated calcium channels in the central nervous system
- Reduces the release of excitatory neurotransmitters involved in nociceptive signaling
Contraindications
- Hypersensitivity to mirogabalin or any excipient in the formulation
Adverse Reactions
- Somnolence
- Dizziness
- Weight gain
- Peripheral edema
- Nasopharyngitis
- Constipation
Drug Interactions
- Central nervous system depressants (e.g., opioids, benzodiazepines, alcohol) may potentiate sedation and somnolence
- Drugs associated with fluid retention or peripheral edema (e.g., thiazolidinediones) may increase risk of edema
Curated Content: Needs Vetting Before Put to Clinical Use