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NERVOUS SYSTEM › ANALGESICS › OTHER ANALGESICS AND ANTIPYRETICS › Other analgesics and antipyretics
nefopam
N02BG06
Forms & Strengths
- Oral tablets: 30 mg
- Solution for injection: 20 mg/2 mL ampoule
Adult Dosing
- Oral: 30 to 90 mg three times daily
- Intramuscular/Intravenous: 20 mg every 4 hours as needed, maximum 120 mg daily
Pediatric Dosing
- Safety and efficacy not established in children under 12 years
Indications
- Management of moderate to severe acute and chronic pain
Mechanism of Action
- Central analgesic acting as a serotonin, norepinephrine, and dopamine reuptake inhibitor
- Does not bind to opioid receptors and lacks respiratory depressant effects
Contraindications
- Hypersensitivity to nefopam
- History of convulsive disorders or epilepsy
- Concomitant use with monoamine oxidase inhibitors (MAOIs)
- Myocardial infarction
- Urinary retention disorders
Adverse Reactions
- Nausea and vomiting
- Sweating
- Dizziness and drowsiness
- Tachycardia and palpitations
- Insomnia and nervousness
- Dry mouth
- Urinary retention
Drug Interactions
- Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis and hyperpyrexia
- Anticholinergic drugs: enhanced anticholinergic adverse effects
- Sympathomimetics: increased risk of cardiovascular side effects
Curated Content: Needs Vetting Before Put to Clinical Use