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NERVOUS SYSTEM › ANALGESICS › ANTIMIGRAINE PREPARATIONS › Other antimigraine preparations
dimetotiazine
N02CX05
Forms & Strengths
- Tablets: 10mg, 20mg
- Injectable solution: 10mg/mL
Adult Dosing
- 30-60mg orally, 2-3 times a day
- 10-20mg IV, repeated as needed
Pediatric Dosing
- Not established for children under 12 years
- 12-18 years: 10-30mg orally, 2-3 times a day
Indications
- Treatment of nausea and vomiting
- Treatment of vertigo and dizziness
- Prevention of motion sickness
Mechanism of Action
- Antihistamine, blocking H1 receptors
- Anticholinergic effect, blocking muscarinic receptors
- Central nervous system depressant effect
Contraindications
- Hypersensitivity to dimethothiazine or other antihistamines
- Narrow-angle glaucoma
- Prostatic hypertrophy
- Obstructive disease of the gastrointestinal tract
Adverse Reactions
- Drowsiness
- Dry mouth
- Dizziness
- Headache
- Constipation
- Urinary retention
Drug Interactions
- Alcohol: increased central nervous system depression
- Barbiturates: increased sedative effect
- MAOIs: increased risk of hypertensive crisis
- Sedatives and tranquilizers: increased sedative effect
Curated Content: Needs Vetting Before Put to Clinical Use