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NERVOUS SYSTEM › ANTIEPILEPTICS › ANTIEPILEPTICS › Barbiturates and derivatives
metharbital
N03AA30
Forms & Strengths
- Tablets: 50mg
- Oral solution: 5mg/mL
Adult Dosing
- Initial dose: 100-200mg tid
- Maintenance dose: 400-600mg tid
Pediatric Dosing
- Infants and children: 5-10mg/kg/day divided tid
Indications
- Seizure disorders
- Epilepsy
Mechanism of Action
- Enhances GABA-mediated inhibition
- Stabilizes neuronal membranes
Contraindications
- Hypersensitivity to barbiturates
- Porphyria
Adverse Reactions
- Drowsiness
- Dizziness
- Ataxia
- Respiratory depression
Drug Interactions
- Concomitant use with CNS depressants: increased sedation
- Concomitant use with MAOIs: increased risk of toxicity
Curated Content: Needs Vetting Before Put to Clinical Use