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NERVOUS SYSTEM › ANTIEPILEPTICS › ANTIEPILEPTICS › Oxazolidine derivatives
trimethadione
N03AC02
Forms & Strengths
- Capsules: 150 mg
- Oral solution: 250 mg/5 mL
Adult Dosing
- Initial: 900 mg/day in 3-4 divided doses
- Maintenance: 900-1200 mg/day
- Maximum dose: 2200 mg/day
Pediatric Dosing
- Initial: 150-200 mg/kg/day in 3-4 divided doses
- Maintenance: 150-300 mg/kg/day
- Maximum dose: 900 mg/day
Indications
- Seizure control in absence seizures
- Treatment of petit mal epilepsy
Mechanism of Action
- Stabilizes neuronal membranes by inhibiting sodium and calcium influx
- Reduces propagation of abnormal electrical discharges
Contraindications
- Hypersensitivity to trimethadione
- Pregnancy and lactation
- Bone marrow depression
Adverse Reactions
- Nausea and vomiting
- Diarrhea and abdominal pain
- Hematologic disorders (e.g., agranulocytosis, aplastic anemia)
- Dermatologic reactions (e.g., rash, urticaria)
Drug Interactions
- Enhanced sedation with CNS depressants (e.g., barbiturates, benzodiazepines)
- Concomitant use with other anti-seizure medications may increase toxicity risk
Curated Content: Needs Vetting Before Put to Clinical Use