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NERVOUS SYSTEM › ANTIEPILEPTICS › ANTIEPILEPTICS › Carboxamide derivatives
eslicarbazepine
N03AF04
Forms & Strengths
- Tablets: 800mg, 600mg
- Oral suspension
Adult Dosing
- Initial dose: 400mg once daily, increase to 800mg after 1-2 weeks
- Maintenance dose: 800mg once daily, may increase to 1200mg
- Maximum dose: 1200mg once daily
Pediatric Dosing
- Children (≥ 4 years): initial 10mg/kg/day, maintenance 15-30mg/kg/day, max 1200mg/day
Indications
- Adjunctive therapy for partial-onset seizures
- Treatment of partial-onset seizures in epilepsy
Mechanism of Action
- Blocks voltage-gated sodium channels
- Decreases release of excitatory neurotransmitters
Contraindications
- Hypersensitivity to eslicarbazepine or oxcarbazepine
- Concomitant use with other sodium channel blockers
Adverse Reactions
- Dizziness
- Somnolence
- Headache
- Nausea
- Vomiting
- Fatigue
Drug Interactions
- Concomitant use with strong CYP3A4 inhibitors (e.g. ketoconazole)
- Phenytoin: increased phenytoin levels
- Carbamazepine: decreased eslicarbazepine levels
Curated Content: Needs Vetting Before Put to Clinical Use