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NERVOUS SYSTEM › ANTIEPILEPTICS › ANTIEPILEPTICS › Fatty acid derivatives
valpromide
N03AG02
Forms & Strengths
- Valpromide is available as 200mg and 400mg oral tablets
- Other forms include injectable solution and suppository
Adult Dosing
- Anticonvulsant dosing: 800-1200mg per day in 2-3 divided doses
- Migraine prophylaxis: 400-800mg per day in 2 divided doses
Pediatric Dosing
- Dosage for children varies by weight and indication
- Typically, dosing starts at 15mg/kg/day, with titration as needed
Indications
- Epilepsy, various seizure types
- Migraine prophylaxis
- Treatment of manic episodes in bipolar disorder
Mechanism of Action
- Exact mechanism unclear
- Modulation of sodium and calcium channels, neurotransmitter effects
Contraindications
- Hepatic dysfunction or active liver disease
- Pregnancy and lactation
- Known hypersensitivity to valpromide or valproate
Adverse Reactions
- Gastrointestinal: nausea, vomiting, diarrhea
- Hepatic: elevated liver enzymes, rare hepatotoxicity
- CNS: tremor, drowsiness, ataxia
Drug Interactions
- Increased risk of hepatotoxicity with concomitant aspirin or acetaminophen use
- Interactions with phenobarbital, phenytoin, and carbamazepine due to cytochrome P450 effects
Curated Content: Needs Vetting Before Put to Clinical Use