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NERVOUS SYSTEM › ANTIEPILEPTICS › ANTIEPILEPTICS › Fatty acid derivatives
vigabatrin
N03AG04
Forms & Strengths
- 250mg, 500mg tablets
- 500mg Powder for Oral Solution
Adult Dosing
- Initial dose: 500mg twice daily
- Titrate to 1000mg twice daily
- Maximum dose: 3000mg daily
Pediatric Dosing
- Infants > 1 month: 50-100mg/kg/day
- Children 2-12 years: 40-80mg/kg/day
- Adolescents > 12 years: 500-1000mg twice daily
Indications
- Treatment of resistant partial epilepsy
- Treatment of infantile spasms (West syndrome)
Mechanism of Action
- Irreversibly inhibits GABA transaminase
- Increases brain GABA concentrations
- Enhances synaptic inhibition
Contraindications
- Hypersensitivity to vigabatrin or components
- Severe renal impairment
Adverse Reactions
- Somnolence, fatigue, dizziness
- Weight gain, anorexia, nausea
- Psychotic episodes, depression, anxiety
- Mild to severe visual field defect
Drug Interactions
- Phenytoin: decreases efficacy
- Aluminium or magnesium containing antacids: decreases absorption
- Clonazepam, phenobarbital: additive sedation
Curated Content: Needs Vetting Before Put to Clinical Use