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NERVOUS SYSTEM › ANTIEPILEPTICS › ANTIEPILEPTICS › Fatty acid derivatives
tiagabine
N03AG06
Forms & Strengths
- Tablets: 2mg, 4mg, 6mg, 8mg, 10mg, 12mg, 16mg
- Oral solution: 5mg/mL
Adult Dosing
- Initial dose: 4mg once daily
- Titration: 4-8mg increments at weekly intervals
- Maintenance dose: 16-56mg daily in 2-4 divided doses
Pediatric Dosing
- Children 12-18 years: initial dose 4mg once daily, titrate as for adults
- Children under 12 years: not recommended due to lack of data
Indications
- Adjunctive treatment of partial seizures
- Adjunctive treatment of generalised seizures of the tonic-clonic type
Mechanism of Action
- Selective inhibitor of the GABA transporter 1 (GAT1)
- Increases synaptic GABA levels, enhancing inhibitory neurotransmission
Contraindications
- Hypersensitivity to tiagabine or any component
- Severe hepatic impairment or significant liver disease
Adverse Reactions
- Dizziness, somnolence, fatigue, asthenia
- Anxiety, depression, psychosis
- Nausea, abdominal pain, diarrhoea
- Tremor, ataxia, muscle weakness
Drug Interactions
- Carbamazepine, phenytoin, phenobarbital: decreased tiagabine levels
- Valproate: increased tiagabine levels
- Other antiepileptic drugs: caution due to potential for pharmacodynamic interactions
Curated Content: Needs Vetting Before Put to Clinical Use