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sultiame

N03AX03

Forms & Strengths

tablets 50mg
tablets 200mg

Adult Dosing

initial dose 200-400mg/day
maintenance dose 200-800mg/day
max dose 800mg/day

Pediatric Dosing

2-4 years: 20-50mg/kg/day
5-12 years: 10-30mg/kg/day
max dose 800mg/day

Indications

epilepsy
partial seizures
tonic-clonic seizures

Mechanism of Action

inhibits carbonic anhydrase
reduces neuronal excitability

Contraindications

hypersensitivity to sultiame
severe hepatic impairment
severe renal impairment

Adverse Reactions

drowsiness
dizziness
nausea
vomiting
diarrhea

Drug Interactions

increases phenytoin levels
decreases valproate levels
interacts with other carbonic anhydrase inhibitors

Curated Content: Needs Vetting Before Put to Clinical Use