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NERVOUS SYSTEM › ANTIEPILEPTICS › ANTIEPILEPTICS › Other antiepileptics
stiripentol
N03AX17
Forms & Strengths
- Capsules: 250mg, 500mg
- Oral solution: 50mg/mL
Adult Dosing
- Initial dose: 50mg/kg/day, titrated to 100mg/kg/day
- Maximum dose: 3000mg/day
- Dosage adjustment based on weight, renal function, and concomitant medications
Pediatric Dosing
- Neonates and infants: 50mg/kg/day divided every 8-12 hours
- Children: initial dose 25-50mg/kg/day, titrated to effect
- Monitoring of liver function and serum concentrations recommended
Indications
- Severe myoclonic epilepsy in infancy (Dravet syndrome)
- Adjunctive therapy in epilepsy
Mechanism of Action
- Inhibits carbonic anhydrase
- Enhances GABAergic activity
- Inhibits NMDA receptor-mediated neurotransmission
Contraindications
- Known hypersensitivity to stiripentol
- Severe liver dysfunction
- Severe renal dysfunction
Adverse Reactions
- Somnolence, fatigue, drowsiness
- Nausea, vomiting, diarrhea
- Increased risk of infections
- Ataxia, tremors, and other coordination disorders
Drug Interactions
- CYP3A4 and CYP2C19 substrate and inhibitor
- Interaction with valproate, clobazam, and phenytoin
- Concomitant use with CNS depressants may enhance sedative effects
Curated Content: Needs Vetting Before Put to Clinical Use