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NERVOUS SYSTEM › ANTIEPILEPTICS › ANTIEPILEPTICS › Other antiepileptics
lacosamide
N03AX18
Forms & Strengths
- Tablets: 50mg, 100mg, 150mg, 200mg
- Solution for injection: 10mg/mL
- Solution for infusion: 10mg/mL
- Vial for injection/infusion: 20mL
Adult Dosing
- Initial dose: 50mg twice daily
- Titration: increase by 50mg weekly
- Maximum dose: 400mg daily
Pediatric Dosing
- Children <4 years: Not established
- Children 4-17 years: Initial dose: 50mg/day, Titration: increase by 50mg weekly
- Children >17 years: Use adult dosing
- Maximum dose: 300mg daily for <17 years
Indications
- Partial-onset seizures
- Adjunctive therapy for primary generalized tonic-clonic seizures
- Monotherapy or adjunctive therapy for partial-onset seizures
Mechanism of Action
- Selective high-affinity ligand for synaptic vesicle protein SV2A
- Enhancement of slow inactivation of sodium channels
- Stabilization of hyperexcited neural membranes
Contraindications
- Hypersensitivity to lacosamide
- None known, but caution advised in severe cardiac conduction disorders
Adverse Reactions
- Dizziness
- Headache
- Diplopia
- Nausea
- Vomiting
- Fatigue
- Infection
- Somnolence
Drug Interactions
- Enzyme-inducing AEDs: Decreased lacosamide levels
- Omeprazole: No significant interaction
- CYP2C19: Potent inhibitors may decrease lacosamide metabolism
Curated Content: Needs Vetting Before Put to Clinical Use