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NERVOUS SYSTEM › ANTIEPILEPTICS › ANTIEPILEPTICS › Other antiepileptics
perampanel
N03AX22
Forms & Strengths
- Tablets: 2mg, 4mg, 6mg, 8mg, 10mg, 12mg
- Oral suspension: 0.5mg/mL
Adult Dosing
- Initial dose: 2mg orally once daily at bedtime
- Titrate dose every week by 2mg until 4-12mg/day as needed and tolerated
- Maximum dose: 12mg/day
Pediatric Dosing
- For patients 12 years and older: same as adult dosing
- For patients 4 to less than 12 years: initial dose 0.25mg/kg (up to 2mg) orally once daily at bedtime
- Titrate dose every week by 0.25mg/kg (up to 2mg) until 4-12mg/day as needed and tolerated
Indications
- Partial-onset seizures with or without secondary generalized seizures
- Primary generalized tonic-clonic seizures
Mechanism of Action
- Selective, non-competitive antagonist of the AMPA receptor
- Inhibits excitatory neurotransmission
Contraindications
- Hypersensitivity to perampanel or its components
- Severe hepatic impairment
Adverse Reactions
- Dizziness
- Somnolence
- Fatigue
- Irritability
- Aggression
- Agitation
- Anger
- Anxiety
- Hostility
Drug Interactions
- May increase the effects of CNS depressants (e.g., alcohol, barbiturates, benzodiazepines, opioids)
- Concomitant use with carbamazepine and other strong CYP3A4 inducers may decrease perampanel levels
- Perampanel may enhance the effects of midazolam
Curated Content: Needs Vetting Before Put to Clinical Use