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NERVOUS SYSTEM › ANTI-PARKINSON DRUGS › ANTICHOLINERGIC AGENTS › Tertiary amines
trihexyphenidyl
N04AA01
Forms & Strengths
- Tablets: 2mg, 5mg
- Elixir: 2mg/5mL
- Capsules: 2mg, 5mg
Adult Dosing
- Initial dose: 1mg, 1-2 times daily
- Maintenance dose: 5-15mg daily in divided doses
- Maximum dose: 20mg daily
Pediatric Dosing
- Initial dose: 0.25mg/kg/day in 3 divided doses
- Maintenance dose: 0.375-1.25mg/kg/day in 3 divided doses
- Maximum dose: not established
Indications
- Symptomatic treatment of parkinsonian syndrome
- Treatment of extrapyramidal symptoms (e.g., drug-induced parkinsonism)
- Treatment of tremors
Mechanism of Action
- Anticholinergic agent
- Blocks acetylcholine receptors in the CNS
- Inhibits the action of acetylcholine in the striatum
Contraindications
- Glaucoma
- Intestinal obstruction
- Urethral obstruction
- Myasthenia gravis
Adverse Reactions
- Dry mouth
- Dizziness
- Confusion
- Constipation
- Urinary retention
- Blurred vision
Drug Interactions
- MAOIs: increased risk of hypertensive crisis
- Tricyclic antidepressants: increased anticholinergic effects
- Antihistamines: increased sedative effects
- Antipsychotics: increased risk of extrapyramidal symptoms
Curated Content: Needs Vetting Before Put to Clinical Use