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NERVOUS SYSTEM › ANTI-PARKINSON DRUGS › ANTICHOLINERGIC AGENTS › Tertiary amines
metixene
N04AA03
Adult Dosing
- Initial dose: 5mg, 2-3 times daily
- Max dose: 15mg/day
Pediatric Dosing
- Not recommended for children under 12
Indications
- Symptomatic treatment of Parkinson's disease
- Extrapyramidal reactions caused by antipsychotics
Mechanism of Action
- Anticholinergic, blocks M1/M2 muscarinic receptors in CNS
- Inhibits acetylcholine in basal ganglia
Contraindications
- Narrow angle glaucoma
- Myasthenia gravis
- Severe intestinal atony
Adverse Reactions
- Dry mouth
- Blurred vision
- Dizziness
- Urinary retention
- Confusion
Drug Interactions
- Concomitant use with antihistamines, MAOIs, or TCAs may increase anticholinergic effects
- Interaction with atropine may increase risk of side effects
Curated Content: Needs Vetting Before Put to Clinical Use