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NERVOUS SYSTEM › ANTI-PARKINSON DRUGS › ANTICHOLINERGIC AGENTS › Ethers chemically close to antihistamines
etanautine
N04AB01
Forms & Strengths
- Tablets: 25mg, 50mg
- Oral solution: 5mg/5mL
Adult Dosing
- Initial dose: 25mg three times daily
- Maintenance dose: 50mg three times daily
- Maximum dose: 200mg/day
Pediatric Dosing
- Children under 12 years: not recommended
- Children 12-18 years: initial dose 25mg three times daily, maintenance dose 50mg three times daily
Indications
- Symptomatic treatment of Parkinson's disease
- Treatment of extrapyramidal symptoms caused by antipsychotic therapy
Mechanism of Action
- Anticholinergic and antihistaminic properties
- Blocks acetylcholine receptors in the central nervous system
Contraindications
- Hypersensitivity to etanautine or other anticholinergic agents
- Narrow-angle glaucoma
- Prostatic hypertrophy
- Obstruction of the gastrointestinal tract
Adverse Reactions
- Dry mouth
- Dizziness
- Drowsiness
- Constipation
- Blurred vision
- Urinary retention
Drug Interactions
- Antipsychotics: increased risk of extrapyramidal symptoms
- MAOIs: increased risk of hypertensive crisis
- Sedatives and hypnotics: enhanced sedative effects
Curated Content: Needs Vetting Before Put to Clinical Use