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NERVOUS SYSTEM › ANTI-PARKINSON DRUGS › DOPAMINERGIC AGENTS › Dopamine agonists
pergolide
N04BC02
Forms & Strengths
- Tablets: 0.05mg, 0.1mg, 0.25mg, 0.5mg, 1mg
- Oral solution
Adult Dosing
- Initial dose: 0.05mg/day
- Titration: increase by 0.1-0.25mg every 3 days
- Maintenance: 1-5mg/day in divided doses
Pediatric Dosing
- Not recommended for children
- Limited data available
Indications
- Treatment of Parkinson's disease
- Adjunct to levodopa/carbidopa therapy
Mechanism of Action
- Dopamine agonist
- Stimulates dopamine D2 receptors
- Increases dopamine activity in brain
Contraindications
- Hypersensitivity to pergolide
- Severe mental disorders
- Uncontrolled hypertension
Adverse Reactions
- Nausea
- Vomiting
- Dizziness
- Headache
- Hallucinations
- Confusion
Drug Interactions
- Levodopa/carbidopa: increased risk of dyskinesia
- Antipsychotics: antagonizes pergolide effects
- MAOIs: increased risk of hypertensive crisis
Curated Content: Needs Vetting Before Put to Clinical Use