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NERVOUS SYSTEM › ANTI-PARKINSON DRUGS › DOPAMINERGIC AGENTS › Dopamine agonists
dihydroergocryptine mesylate
N04BC03
Forms & Strengths
- Tablets: 10mg, 20mg, 30mg
- Oral solution: 10mg/5mL
Adult Dosing
- Initial dose: 10-20mg orally once daily
- Maintenance dose: 20-30mg orally once daily
- Maximum dose: 30mg orally once daily
Pediatric Dosing
- Not established for patients under 18 years of age
Indications
- Parkinson's disease
- Monotherapy or adjunct to levodopa
Mechanism of Action
- Stimulates dopamine receptors in the brain
- Increases dopamine levels
- Blocks serotonin receptors
Contraindications
- Hypersensitivity to ergot alkaloids
- Severe peripheral artery disease
- Severe hepatic impairment
Adverse Reactions
- Nausea
- Vomiting
- Diarrhea
- Headache
- Dizziness
- Hallucinations
Drug Interactions
- Concomitant use with MAOIs may increase risk of hypertensive crisis
- Concomitant use with beta blockers may increase risk of ergotism
- Concomitant use with other dopamine agonists may increase risk of adverse reactions
Curated Content: Needs Vetting Before Put to Clinical Use