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opicapone

N04BX04

Forms & Strengths

50mg capsules

Adult Dosing

50mg orally once daily
administer at bedtime

Pediatric Dosing

not established

Indications

treatment of Parkinson's disease
as adjunct to levodopa/DOPA decarboxylase inhibitors

Mechanism of Action

selective and reversible catechol-O-methyltransferase (COMT) inhibitor
increases bioavailability of levodopa

Contraindications

none established

Adverse Reactions

dyskinesia
constipation
hypertension
neuropathy

Drug Interactions

levodopa: increased bioavailability
DOPA decarboxylase inhibitors: increased bioavailability
antipsychotics: potential decreased efficacy

Curated Content: Needs Vetting Before Put to Clinical Use