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NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Phenothiazines with aliphatic side-chain
triflupromazine
N05AA05
Forms & Strengths
- Tablets: 10mg, 20mg
- Injectable solution: 10mg/mL, 20mg/mL
- Suppository: 10mg, 20mg
Adult Dosing
- Oral: 10-20mg every 4-6 hours as needed
- IM/IV: 10-20mg every 4-6 hours as needed
- Rectal: 10-20mg every 4-6 hours as needed
Pediatric Dosing
- Children over 12 years: same as adult dose
- Children under 12 years: not recommended
Indications
- Schizophrenia
- Anxiety disorders
- Severe nausea and vomiting
- Preoperative sedation
Mechanism of Action
- Blocks dopamine D2 receptors in the brain
- Antagonizes histamine H1, serotonin, and alpha-adrenergic receptors
- Produces sedative, antiemetic, and antipsychotic effects
Contraindications
- Hypersensitivity to phenothiazines
- Coma or severe CNS depression
- Bone marrow depression
- Severe cardiovascular disease
Adverse Reactions
- Sedation
- Drowsiness
- Dizziness
- Orthostatic hypotension
- Anticholinergic effects
- Extrapyramidal symptoms
- Neuroleptic malignant syndrome
Drug Interactions
- Increases sedative effects with other CNS depressants
- Interacts with anticholinergics, increasing risk of anticholinergic effects
- Increases risk of hypotension with antihypertensives
- May decrease effectiveness of levodopa
Curated Content: Needs Vetting Before Put to Clinical Use