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NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Phenothiazines with aliphatic side-chain
chlorproethazine
N05AA07
Forms & Strengths
- Tablets: 25mg, 50mg, 100mg, 200mg
- Oral solution: 25mg/5mL
- Injectable: 25mg/mL
Adult Dosing
- Acute psychosis: 25-50mg IM or IV, repeat every 1-4 hours as needed
- Severe nausea and vomiting: 10-25mg IV or IM, every 3-4 hours as needed
- Anxiety and tension: 25-50mg orally, every 4-6 hours as needed
Pediatric Dosing
- Children 6-12 years: 10-25mg orally or IM, every 4-6 hours as needed
- Children under 6 years: not recommended
Indications
- Acute psychotic episodes
- Severe nausea and vomiting
- Anxiety and tension
- Preoperative sedation
Mechanism of Action
- Blocks dopamine receptors in the brain, reducing psychotic symptoms
- Has anticholinergic and antihistaminic effects, contributing to sedation and antiemetic effects
Contraindications
- Hypersensitivity to chlorproethazine or other phenothiazines
- Coma or severe CNS depression
- Bone marrow depression
Adverse Reactions
- Sedation, drowsiness, and lethargy
- Anticholinergic effects: dry mouth, constipation, urinary retention
- Extrapyramidal symptoms: parkinsonism, dystonia, akathisia
- Hypotension, orthostatic hypotension
Drug Interactions
- Increased sedation with other CNS depressants
- Additive anticholinergic effects with other anticholinergic agents
- Increased risk of hypotension with antihypertensive agents
Curated Content: Needs Vetting Before Put to Clinical Use