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NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Phenothiazines with piperazine structure
prochlorperazine
N05AB04
Forms & Strengths
- Tablets: 5mg, 10mg
- Suppositories: 25mg
- Ampoules for injection: 12.5mg/mL
Adult Dosing
- Nausea and vomiting: 5-10mg orally 3-4 times daily
- Psychosis and anxiety: 10-50mg orally 2-4 times daily
- Severe cases: 25-50mg IM or IV every 6 hours
Pediatric Dosing
- Nausea and vomiting: 0.4-0.8mg/kg/day orally divided into 3-4 doses
- Children under 2 years or 10kg: contraindicated
- Children 2-12 years: dose reduction and close monitoring required
Indications
- Nausea and vomiting
- Psychosis
- Anxiety
- Schizophrenia
Mechanism of Action
- Dopamine D2 receptor antagonist
- Blocks dopamine receptors in the chemoreceptor trigger zone
- Inhibits prostaglandin-induced emesis
Contraindications
- Hypersensitivity to prochlorperazine or similar drugs
- Pheochromocytoma
- Children under 2 years or 10kg
- Severe CNS depression or coma
Adverse Reactions
- Drowsiness
- Dizziness
- Dry mouth
- Blurred vision
- Extrapyramidal symptoms
- Hypotension
- Agranulocytosis
Drug Interactions
- CNS depressants: additive sedative effects
- Anticholinergic agents: increased risk of extrapyramidal symptoms
- MAOIs: increased risk of serotonin syndrome
Curated Content: Needs Vetting Before Put to Clinical Use