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NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Phenothiazines with piperidine structure
periciazine
N05AC01
Forms & Strengths
- Tablets: 2.5mg, 5mg, 10mg, 20mg
- Injectable solution: 10mg/mL, 20mg/mL
- Oral solution: 2.5mg/5mL
Adult Dosing
- Initial dose: 5-10mg orally twice daily
- Maintenance dose: 20-40mg orally daily
- Maximum dose: 60-100mg orally daily
- Parenteral: 5-10mg IM/IV
Pediatric Dosing
- Not recommended for children under 12 years
- 12-18 years: Initially 2.5-5mg orally twice daily, maintenance 10-20mg daily
Indications
- Schizophrenia
- Acute and chronic psychoses
- Anxiety states
- Psychogenic and organic depressions
Mechanism of Action
- Acts as a dopamine D2 receptor antagonist
- Blocks the action of dopamine in the brain
- Possesses anticholinergic, antihistaminic, and antiadrenergic properties
Contraindications
- Known hypersensitivity to periciazine or other phenothiazine derivatives
- Comatose or severely depressed states
- Bone marrow depression
Adverse Reactions
- Drowsiness
- Dry mouth
- Constipation
- Blurred vision
- Orthostatic hypotension
- Extrapyramidal symptoms
- Neuroleptic malignant syndrome
- Agranulocytosis
Drug Interactions
- Concomitant use with other CNS depressants may increase sedative effects
- Anticholinergic agents may increase risk of anticholinergic side effects
- May enhance the effects of epinephrine and other sympathomimetics
Curated Content: Needs Vetting Before Put to Clinical Use