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NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Butyrophenone derivatives
melperone
N05AD03
Forms & Strengths
- Tablets: 10mg, 25mg, 50mg
- Injectable solution: 50mg/mL
Adult Dosing
- Initial dose: 50-100mg/day
- Maintenance dose: 100-200mg/day
- Elderly: 25-50mg/day
Pediatric Dosing
- Not recommended for children under 12 years old
Indications
- Schizophrenia
- Anxiety disorders
- Agitation
- Aggressive behavior
Mechanism of Action
- Butyrophenone derivative with neuroleptic properties
- Blocks dopamine D2 receptors in the brain
Contraindications
- Hypersensitivity to melperone
- Pheochromocytoma
- Severe hepatic impairment
Adverse Reactions
- Sedation
- Drowsiness
- Dry mouth
- Constipation
- Hypotension
- Extrapyramidal reactions
Drug Interactions
- Increased sedation with CNS depressants
- Antagonism of antihypertensive drugs
- Increased risk of extrapyramidal reactions with other neuroleptics
Curated Content: Needs Vetting Before Put to Clinical Use