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NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Butyrophenone derivatives
moperone
N05AD04
Forms & Strengths
- Tablets: 10mg, 20mg, 50mg
- Injectable solution: 5mg/mL
Adult Dosing
- Initial dose: 10-20mg orally twice daily
- Maintenance dose: 20-50mg orally twice daily
- Maximum dose: 100mg orally per day
Pediatric Dosing
- Not recommended for children under 12 years old
- 12-18 years: 5-10mg orally twice daily, adjust according to response
Indications
- Schizophrenia
- Acute psychosis
- Anxiety disorders
Mechanism of Action
- Antagonism of dopamine D2 receptors
- Serotonin 5-HT2 receptor antagonism
- Histamine H1 receptor antagonism
Contraindications
- Hypersensitivity to moperone
- Severe CNS depression
- Comatose patients
Adverse Reactions
- Drowsiness
- Dry mouth
- Orthostatic hypotension
- Anticholinergic effects
- Extrapyramidal symptoms
Drug Interactions
- Enhanced sedation with other CNS depressants
- Antagonism of antiparkinsonian agents
- Increased risk of hypotension with antihypertensives
Curated Content: Needs Vetting Before Put to Clinical Use