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NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Butyrophenone derivatives
droperidol
N05AD08
Forms & Strengths
- 2 mg/mL injection
- 2.5 mg tablets
Adult Dosing
- 2.5 mg IM or IV for anesthesia
- 1.25-2.5 mg IV for sedation
- 0.625-1.25 mg IV for antiemetic use
Pediatric Dosing
- Not recommended for children under 2 years
- 2-12 years: 0.1-0.2 mg/kg IM or IV for anesthesia
- 2-12 years: 0.05-0.1 mg/kg IV for sedation
Indications
- Anesthesia
- Sedation
- Anti-emetic
- Pre-anesthetic medication
Mechanism of Action
- Dopamine antagonist
- Blocks dopamine receptors in the chemoreceptor trigger zone
Contraindications
- Known or suspected QT prolongation
- Hypersensitivity to droperidol or other butyrophenones
- Pheochromocytoma
Adverse Reactions
- Hypotension
- Bradycardia
- Tachycardia
- QT interval prolongation
- Torsades de pointes
- Extrapyramidal reactions
Drug Interactions
- Central nervous system depressants: additive sedative effect
- Phenothiazines and thioxanthenes: increased risk of extrapyramidal reactions
- MAOIs: increased risk of hypotension and extrapyramidal reactions
- CNS stimulants: antagonized effects
Curated Content: Needs Vetting Before Put to Clinical Use