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NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Indole derivatives
sertindole
N05AE03
Forms & Strengths
- 20mg tablets
- Oral liquid 4mg/2mL
Adult Dosing
- Initial dose: 4mg twice daily
- Titrate upward to 12-20mg daily if needed and if well tolerated
- Dose may be increased every 4-7 days
Pediatric Dosing
- Not established for children under 18 years
Indications
- Treatment of schizophrenia
- Reduction of symptoms in patients with schizophrenia
Mechanism of Action
- Antagonist at dopamine D2 receptors
- Antagonist at serotonin 5-HT2A receptors
- Inhibition of dopaminergic transmission in the mesolimbic pathway
Contraindications
- Known QT interval prolongation
- Arrhythmias
- Severe cardiac disorders
- Taking medications known to prolong the QT interval
Adverse Reactions
- QT interval prolongation
- Arrhythmias
- Cardiac arrest
- Sudden death
- Extrapyramidal symptoms
- Weight gain
- Hyperlipidemia
Drug Interactions
- Should not be used with other drugs that prolong the QT interval
- Use with caution with CYP2D6 inhibitors (e.g. fluoxetine, paroxetine)
- Interactions may increase risk of QT prolongation
Curated Content: Needs Vetting Before Put to Clinical Use