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NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Thioxanthene derivatives
flupentixol
N05AF01
Forms & Strengths
- Oral tablets: 0.5mg, 1mg, 3mg
- Oral drops: 0.5mg/0.5ml, 1mg/1ml, 2mg/1ml
- Depot injection: 10mg/ml, 20mg/ml
Adult Dosing
- Schizophrenia: 3mg orally tid, adjust to 1-5mg tid
- Depression: 1mg orally bid, adjust to 0.5-2mg bid
- Depot injection: 20-40mg im every 2-4 weeks
Pediatric Dosing
- Not recommended for children under 12 years old
- 12 years and older: 0.25-0.5mg orally tid, adjust to 0.5-2mg tid
Indications
- Treatment of schizophrenia
- Treatment of depressive states
- Treatment of anxiety disorders
Mechanism of Action
- Antagonism of dopamine D2 receptors
- Antagonism of serotonin 5-HT2 receptors
- Blockade of alpha-1 adrenergic receptors
Contraindications
- Hypersensitivity to flupentixol or other thioxanthenes
- Comatose or severe depressive states
- Phaeochromocytoma
- Pregnancy and lactation
Adverse Reactions
- Extrapyramidal symptoms
- Drowsiness
- Dry mouth
- Orthostatic hypotension
- Weight gain
- Increased risk of stroke and transient ischaemic attack in elderly patients with dementia
Drug Interactions
- Increased risk of QT prolongation with other QT-prolonging medications
- Enhanced sedative effect with other CNS depressants
- Enhanced hypotensive effect with antihypertensive agents
- Reduced efficacy with dopamine agonists
- Increased risk of neuroleptic malignant syndrome with lithium
Curated Content: Needs Vetting Before Put to Clinical Use