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NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Thioxanthene derivatives
clopenthixol
N05AF02
Forms & Strengths
- Tablets: 10mg, 20mg, 30mg, 40mg, 50mg
- Injectable solution: 50mg/ml, 200mg/ml
- Oral drops: 20mg/ml
Adult Dosing
- Acute psychosis: 20-50mg orally, tid
- Chronic psychosis: 20-100mg orally, bid
- Severe psychosis: 50-200mg IM, every 2-3 days
Pediatric Dosing
- Not recommended for children under 12 years
- Children 12 years and older: dose as for adults, adjusted for weight and condition
Indications
- Schizophrenia
- Other psychoses
- Acute mania
- Severe anxiety
Mechanism of Action
- Blocks dopamine D2 receptors in the brain
- Has anticholinergic and antihistaminic properties
- Inhibits serotonin reuptake
Contraindications
- Hypersensitivity to clopenthixol
- Bone marrow depression
- Severe liver disease
- Phaeochromocytoma
Adverse Reactions
- Extrapyramidal symptoms
- Drowsiness
- Dry mouth
- Hypotension
- Increased appetite and weight gain
- Seizures
Drug Interactions
- Enhanced sedation with CNS depressants
- Increased risk of extrapyramidal symptoms with lithium
- Reduced antipsychotic efficacy with carbamazepine
- Increased risk of QT prolongation with other QT-prolonging agents
Curated Content: Needs Vetting Before Put to Clinical Use