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NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Diazepines, oxazepines, thiazepines and oxepines
quetiapine
N05AH04
Forms & Strengths
- Tablets: 25mg, 50mg, 100mg, 150mg, 200mg, 300mg
- Extended-release tablets: 50mg, 150mg, 200mg, 300mg, 400mg
- Oral suspension: 25mg/mL
Adult Dosing
- Schizophrenia: 150-750mg/day, divided into 2-3 doses
- Bipolar disorder: 300-600mg/day, divided into 2 doses
- Major depressive disorder: 50-300mg/day, at bedtime
- Anxiety disorders: 50-150mg/day, divided into 2-3 doses
Pediatric Dosing
- Schizophrenia (13-17 years): 400-800mg/day, divided into 2-3 doses
- Bipolar disorder (10-17 years): 400-600mg/day, divided into 2 doses
- Major depressive disorder (10-17 years): 50-200mg/day, at bedtime
Indications
- Treatment of schizophrenia
- Treatment of bipolar disorder
- Treatment of major depressive disorder
- Treatment of generalized anxiety disorder
- Treatment of attention deficit hyperactivity disorder (off-label)
Mechanism of Action
- Antagonism of dopamine D2 receptors
- Antagonism of serotonin 5-HT2A receptors
- Inhibition of norepinephrine reuptake
- Modulation of histamine and acetylcholine receptors
Contraindications
- Hypersensitivity to quetiapine or any components of the formulation
- Concomitant use with CYP3A4 inhibitors (e.g. ketoconazole, ritonavir)
Adverse Reactions
- Sedation
- Drowsiness
- Dizziness
- Dry mouth
- Constipation
- Weight gain
- Increased risk of diabetes and dyslipidemia
- Increased risk of seizures and orthostatic hypotension
Drug Interactions
- Phenytoin: decreased quetiapine levels
- Carbamazepine: decreased quetiapine levels
- Rifampin: decreased quetiapine levels
- Ketoconazole: increased quetiapine levels
- CNS depressants: additive sedation and hypotension
Curated Content: Needs Vetting Before Put to Clinical Use