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NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Diazepines, oxazepines, thiazepines and oxepines
olanzapine and samidorphan
N05AH53
Forms & Strengths
- Tablets: 5mg/10mg, 10mg/10mg, 15mg/10mg, 20mg/10mg olanzapine/samidorphan
- Oral formulation
Adult Dosing
- Initial dose: 10mg/10mg once daily
- Dose range: 5mg/10mg to 20mg/10mg once daily
- Titration: increase by 5mg/10mg every week
Pediatric Dosing
- Not established for patients under 18 years old
Indications
- Treatment of schizophrenia
- Treatment of bipolar I disorder
Mechanism of Action
- Olanzapine: antagonist at dopamine D2, serotonin 5-HT2A receptors
- Samidorphan: mu-opioid receptor antagonist, mitigates olanzapine-associated weight gain
Contraindications
- Hypersensitivity to olanzapine, samidorphan, or any component
- Pregnancy, or women who are breast-feeding
Adverse Reactions
- Weight gain, somnolence, dry mouth, dizziness, nausea, asthenia
- Increased risk of stroke, transient ischemic attack in elderly
Drug Interactions
- CNS-active drugs, fluvoxamine, carbamazepine, omeprazole, rifampicin
- Avoid concomitant use with opioids, benzodiazepines, or other central nervous system depressants
Curated Content: Needs Vetting Before Put to Clinical Use