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NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Benzamides
sulpiride
N05AL01
Forms & Strengths
- Tablets: 50mg, 100mg, 200mg, 400mg, 600mg (Europe), 200mg, 300mg (Japan)
- Oral solution: 20mg/1ml, 40mg/1ml
- Injectable solution: 50mg/1ml
Adult Dosing
- Schizophrenia: 400-800mg/day, divided into 2 or 3 doses
- Acute psychotic episodes: 600-1200mg/day, divided into 2 or 3 doses
- Depressive states: 150-300mg/day, divided into 2 or 3 doses
Pediatric Dosing
- Schizophrenia (13-18 years): 200-600mg/day, divided into 2 or 3 doses, gradually increase
- Not recommended for children under 13 years old due to lack of data
Indications
- Schizophrenia and other psychoses
- Treatment of depressive states
- Alcohol dependence as part of a comprehensive treatment program
- Anxiety disorders
Mechanism of Action
- Selective blocking of dopamine D2 receptors in the limbic system
- Weak blocking of D1 receptors
- Inhibition of presynaptic dopamine receptors, increasing dopaminergic neurotransmission
Contraindications
- Known hypersensitivity to sulpiride
- Pheochromocytoma
- Breast cancer, as sulpiride may elevate prolactin levels
- Severe renal insufficiency, unless hemodialysis is performed
Adverse Reactions
- Extrapyramidal disorders (dystonia, parkinsonism, akathisia)
- Hyperprolactinemia (galactorrhea, amenorrhea, gynecomastia)
- Sedation, somnolence, drowsiness
- Anticholinergic effects (dry mouth, constipation)
- Cardiovascular effects (QT prolongation, ventricular arrhythmia)
Drug Interactions
- Risperidone: increased risk of extrapyramidal symptoms
- Levodopa: decreased efficacy of levodopa
- Haloperidol: increased risk of extrapyramidal symptoms
- Antihypertensives: increased risk of hypotension
- Fluoxetine: increased risk of serotonin syndrome
Curated Content: Needs Vetting Before Put to Clinical Use