← Search & browse all drugs
NERVOUS SYSTEM › PSYCHOLEPTICS › ANXIOLYTICS › Benzodiazepine derivatives
chlordiazepoxide
N05BA02
Forms & Strengths
- Tablets: 5mg, 10mg, 25mg
- Capsules: 5mg, 10mg, 25mg
- Oral solution: 5mg/5mL
Adult Dosing
- Anxiety: 5-10mg tid-qid
- Alcohol withdrawal: 50-100mg q6-8h
- Sedation: 5-10mg hs
Pediatric Dosing
- 5-12 years: 5mg bid-tid
- >= 12 years: adult dose
- Dose adjustments based on weight and clinical response
Indications
- Anxiety disorders
- Alcohol withdrawal syndrome
- Sedation for medical procedures
Mechanism of Action
- Potentiates GABA activity
- Enhances inhibitory neurotransmission
- Produces anxiolytic, sedative, and muscle relaxant effects
Contraindications
- Hypersensitivity to benzodiazepines
- Acute narrow-angle glaucoma
- Severe hepatic or respiratory impairment
Adverse Reactions
- Drowsiness
- Dizziness
- Ataxia
- Confusion
- Anterograde amnesia
Drug Interactions
- CNS depressants: additive sedation
- Alcohol: increased sedation and CNS depression
- CYP3A4 inhibitors: increased chlordiazepoxide levels
Curated Content: Needs Vetting Before Put to Clinical Use