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NERVOUS SYSTEM › PSYCHOLEPTICS › ANXIOLYTICS › Benzodiazepine derivatives
potassium clorazepate
N05BA05
Forms & Strengths
- Capsules: 3.75 mg, 7.5 mg, 11.25 mg, 15 mg
- Tablets: 3.75 mg, 7.5 mg, 11.25 mg, 15 mg, 22.5 mg
Adult Dosing
- Anxiety: 7.5 to 15 mg PO tid or qid, max 45 mg/day
- Alcohol withdrawal: 30 to 120 mg/day PO in divided doses
Pediatric Dosing
- Children > 12 years: 7.5 to 15 mg PO bid or tid
- Use in children < 12 years not recommended
Indications
- Anxiety disorders
- Alcohol withdrawal symptoms
- Muscle relaxation
Mechanism of Action
- Potentiates GABA effects by increasing chloride ion influx through GABA_A receptors
- Enhances neural membrane permeability to chloride ions
- Produces sedative, hypnotic, anxiolytic, and anticonvulsant effects
Contraindications
- Known hypersensitivity to benzodiazepines or potassium clorazepate
- Glaucoma, acute narrow-angle
- Severe respiratory depression
- Sleep apnea syndrome
Adverse Reactions
- Drowsiness
- Dizziness
- Ataxia
- Confusion
- Memory impairment
- Dependence and withdrawal symptoms
Drug Interactions
- Alcohol: enhances CNS depression
- Barbiturates: additive CNS depression
- Opioids: additive CNS and respiratory depression
- Sedating antihistamines: additive CNS depression
Curated Content: Needs Vetting Before Put to Clinical Use